New research published on the mechanism of mitochondrial DAMPs (Damage Associated Molecular Patterns) involved in SIRS (the Systemic Inflammatory Response Syndrome)

Sat 01 February 2020

A report entitled "Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma" has been published in Crit Care Med 2020 Feb;48(2):e123-e132, doi: 10.1097/CCM.0000000000004094, PMID: 31939811. The work showed that mitochondrial formylated peptides act as DAMPs and both activate and desensitize neutrophils. Formyl peptide receptor-1 blockade prevents desensitization, potentially both diminishing systemic inflammatory response syndrome and protecting the host against secondary infection after tissue trauma or primary infection. The results provide insight for new approaches to prevent secondary infections after trauma.